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AICAR

AICAR

£35.00 GBP
Dose

Product Overview

AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is a synthetic nucleoside analogue that functions as an AMP-activated protein kinase (AMPK) activator. This compound mimics the cellular effects of exercise by activating metabolic pathways typically stimulated during physical activity, making it a valuable research tool for studying cellular energy metabolism.

Molecular Specifications

  • Chemical Name: 5-amino-1-β-D-ribofuranosylimidazole-4-carboxamide
  • Molecular Formula: C9H14N4O5
  • Molecular Weight: 258.23 g/mol
  • CAS Number: 2627-69-2
  • Formulation: Compressed tablets
  • Purity: ≥98% (HPLC verified)

Structural Characteristics

AICAR consists of an imidazole ring system attached to a ribose sugar moiety. This nucleoside structure allows it to be phosphorylated intracellularly to form ZMP (5-aminoimidazole-4-carboxamide ribonucleoside monophosphate), which acts as an AMP mimetic and AMPK activator.

Research Applications

This compound is utilized in various research contexts investigating:

  • AMPK activation and cellular energy sensing mechanisms
  • Metabolic pathway regulation and glucose homeostasis
  • Exercise mimetic effects and metabolic adaptation
  • Mitochondrial biogenesis and oxidative metabolism
  • Fatty acid oxidation and lipid metabolism studies
  • Cellular stress response and energy conservation pathways

Storage & Handling

  • Storage Temperature: Room temperature (15-30°C), dry conditions
  • Stability: 36 months when stored properly in original packaging
  • Formulation: Immediate-release tablets for consistent dosing
  • Light Sensitivity: Store in original container, protect from light

Quality Assurance

Each batch undergoes comprehensive analytical testing including HPLC purity analysis, mass spectrometry verification, tablet uniformity testing, dissolution studies, and microbial testing. Certificate of Analysis provided with each shipment.

For research purposes only. Not for human consumption or therapeutic use.

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