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IGF1-LR3

IGF1-LR3

£140.00 GBP
Dose

Product Overview

IGF1-LR3 (Insulin-like Growth Factor-1 Long R3) is a synthetic analogue of human IGF-1, engineered with enhanced stability and bioactivity. This 83-amino acid polypeptide features an N-terminal extension of 13 amino acids and an arginine substitution at position 3, resulting in significantly reduced binding affinity to IGF-binding proteins and extended half-life compared to native IGF-1.

Molecular Specifications

  • Molecular Formula: C400H625N111O115S7
  • Molecular Weight: 9117.5 Da
  • Sequence Length: 83 amino acids
  • Purity: ≥98% (HPLC verified)
  • Appearance: White lyophilized powder
  • Solubility: Soluble in sterile water or bacteriostatic water

Structural Modifications

The LR3 variant incorporates critical structural modifications that distinguish it from endogenous IGF-1:

  • 13-amino acid N-terminal extension derived from IGF-1 Ec domain
  • Arginine substitution at position 3 (Glu→Arg)
  • Reduced IGF-binding protein affinity (100-1000 fold decrease)
  • Extended circulating half-life (20-30 hours vs 10-12 minutes for native IGF-1)

Research Applications

IGF1-LR3 is utilized in various research contexts investigating growth factor signaling pathways, cellular proliferation mechanisms, and metabolic regulation studies. The compound's enhanced stability profile makes it particularly suitable for extended experimental protocols.

Storage & Handling

  • Storage Temperature: -20°C (lyophilized), 2-8°C (reconstituted, short-term)
  • Stability: 24 months lyophilized, 30 days reconstituted at 2-8°C
  • Reconstitution: Use sterile water or bacteriostatic water
  • Handling: Avoid repeated freeze-thaw cycles

Quality Assurance

Each batch undergoes comprehensive analytical testing including HPLC purity analysis, mass spectrometry verification, and endotoxin testing. Certificate of Analysis provided with each shipment.

For research purposes only. Not for human consumption or therapeutic use.

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