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CJC-1295 without DAC

CJC-1295 without DAC

£20.00 GBP
Dose

Product Overview

CJC-1295 without DAC is a synthetic analogue of growth hormone-releasing hormone (GHRH) consisting of the first 29 amino acids of GHRH with four amino acid substitutions to prevent degradation by dipeptidyl peptidase IV (DPP-IV) and aminopeptidases. This modification significantly extends the peptide's half-life compared to native GHRH while maintaining its biological activity.

Molecular Specifications

  • Molecular Formula: C152H252N44O42
  • Molecular Weight: 3367.97 Da
  • Sequence Length: 30 amino acids
  • Purity: ≥98% (HPLC verified)
  • Appearance: White lyophilized powder
  • Solubility: Soluble in sterile water and bacteriostatic water

Structural Modifications

The key modifications include substitutions at positions 2, 8, 15, and 27 of the native GHRH sequence:

  • D-Ala² substitution for enhanced stability
  • Gln⁸ substitution to prevent DPP-IV cleavage
  • Ala¹⁵ substitution for improved receptor binding
  • Leu²⁷ substitution for increased half-life

Research Applications

This compound is utilized in various research contexts investigating:

  • Growth hormone releasing hormone receptor pharmacology
  • Pituitary somatotroph cell function and signaling
  • Growth hormone secretion dynamics and pulsatility
  • Peptide stability and degradation pathways
  • Receptor-ligand interaction studies
  • Comparative pharmacokinetic analysis with DAC variants

Storage & Handling

  • Storage Temperature: -20°C (lyophilized), 2-8°C (reconstituted, short-term)
  • Stability: 24 months lyophilized, 30 days reconstituted at 2-8°C
  • Reconstitution: Use sterile water or bacteriostatic water
  • Half-life: Approximately 30 minutes (shorter than DAC variant)

Quality Assurance

Each batch undergoes comprehensive analytical testing including HPLC purity analysis, mass spectrometry verification, amino acid analysis, and endotoxin testing. Certificate of Analysis provided with each shipment.

For research purposes only. Not for human consumption or therapeutic use.

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